Previous studies established that the epigenetic modifier EZH2, which mediates H3K27 trimethylation and heterochromatin formation, can specifically repress the expression of Cxcl9 and Cxcl10 in several tumor entities, leading to the exclusion of cytotoxic T cells and NK cells from the TME29,30. This evidence concerns the gene CXCL9 and neoplasm.