Although increased STAT3 and NF-κB activity in IκBζ-expressing melanoma could explain the elevated expression of IL-6 and IL-1 cytokines, STAT3 and NF-κB inhibition was unable to recover IκBζ-mediated suppression of Cxcl9, Cxcl10, and Ccl5 in melanoma cells (Supplementary Fig. S8a, b). Here, IL6 is linked to melanoma.