NFKBIZ and melanoma: In agreement with these findings, IκBζ did not only interact with HDAC3 and EZH2 in melanoma cells (Fig. 9c), but also led to increased recruitment of HDAC3 and potentially enhanced EZH2-dependent H3K27me3 levels at the promoter regions of Cxcl9, Cxcl10, and Ccl5 (Fig. 9d).