Consequently, the interaction of IκBζ with EZH2 and HDAC3 might be the most upstream event regulating IκBζ target genes in melanoma, whereas IκBζ-mediated gene activation derives from the additional presence of EZH2- and HDAC3-activated STAT3 and p65 at single gene promoters. The gene discussed is NFKBIZ; the disease is melanoma.