Within the bone microenvironment, osteoclastogenesis is driven by RANKL and M-CSF signaling in monocyte/macrophage precursors, which orchestrates the balance of bone remodeling.44 The scRNA-seq analysis revealed that PM could effectively disrupt the transcriptional program of monocyte differentiation into osteoclasts in MM disease states. The gene discussed is TNFSF11; the disease is Miyoshi myopathy.