Multiple factors, such as EZH2, c-MYC, IKZF1, IKZF3, IRF4, and CDK6, which are essential for the proliferation and survival of malignant plasma cells and lymphoma,34,35 were decreased upon treatment with PM in all tested MM and lymphoma cell lines, including MM1S, MM1R, and TMD-8 (Fig. 2b, Supplementary Fig. 2e). This evidence concerns the gene EZH2 and Miyoshi myopathy.