BIVM and central nervous system cancer: ATM, a serine/threonine kinase participates in the DNA damage checkpoint controlling downstream signals responsible for entry into the S phase42 and BIVM-ERCC5 gene encodes a protein involved in DNA repair and polymorphisms of this gene are related to an increased risk of some cancer types such as meningioma, glioma, neuroma, gastric, and breast cancers.43