,11NF2, AKT1E17K, KLF4K409Q, and TRAF7 are the most common mutations observed in meningiomas, and some other somatic driver mutations have been detected at low frequency, such as POLR2A, KDM6A, CHD2, PTEN, CREBPP, FBXW7, BAP1, FOXM1, and PIK3CA.8 Here, PIK3CA is linked to meningioma.