Proteomic analysis and validation of the NF2−/− tumours revealed that Annexin-3 (ANXA3) is over-expressed in all tumours analysed compared to AKT1E17K/TRAF7, KLF4K409Q/TRAF7 tumours, and normal meningeal tissue (Fig. 4d). The gene discussed is ANXA3; the disease is neoplasm.