PIK3CA and meningioma: ,8,9 Meningiomas without NF2 mutations show other somatic driver mutations such as mutations on Tumour necrosis factor receptor-associated factor 7 (TRAF7), Krüppel-like factor 4 (KLF4K409Q), v-akt murine thymoma viral oncogene (AKT1E17K), and Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) which together represent 35% of driver somatic mutation burden in meningioma.10