ATM, a serine/threonine kinase participates in the DNA damage checkpoint controlling downstream signals responsible for entry into the S phase42 and BIVM-ERCC5 gene encodes a protein involved in DNA repair and polymorphisms of this gene are related to an increased risk of some cancer types such as meningioma, glioma, neuroma, gastric, and breast cancers.43 This evidence concerns the gene MARK2 and central nervous system cancer.