AGT and hydrops fetalis: ESPVR slope analysis showed that HF induced systolic dysfunction by acting likely through ANGII, a negative inotropic agent that reduces contractility or systolic performance, as shown by a slope shifted to the right, with a value reduced compared with the control group, which was prevented by cannabidiol (Figure 2E), suggesting that chronic HF-induced systolic dysfunction may implicate a deleterious effect on the molecular mechanisms responsible for cardiomyocyte stimulus-contraction coupling and that cannabidiol could be acting at that level to prevent cellular dysfunction.