PPARG and cardiac hypertrophy: The identified cellular mechanisms through which cannabidiol exerts its cardioprotective effects include reducing oxidative stress and the activation of PPAR-γ, which helps prevent mitochondrial dysfunction by decreasing MCU hyperactivity.PerspectivesCOMPETENCY IN MEDICAL KNOWLEDGE: The outcomes of this study add toward a deeper understanding of the cellular and molecular basis of HF, particularly in regard to cardiac hypertrophy, Ca2+ dynamics, and mitochondrial function of cardiomyocytes.