WNK2 and plexiform neurofibroma: Management includes surgical excision or laser ablation of neurofibromas and supportive measures such as emollients and psychological counseling.11Malignant peripheral nerve sheath tumors require complete resection with clear margins.11Selumetinib, a mitogen-activated protein kinase (MEK) kinase inhibitor, is an emerging treatment option for inoperable plexiform neurofibromas.12Regular monitoring is essential for detecting neoplastic or systemic complications.11