Since the chondroitin sulfate content results from both degradation and production of chondroitin sulfate, sulfotransferase activity and expression of the carbohydrate sulfotransferases CHST11 (adds 4-sulfate to unsulfated chondroitin) and CHST15 (adds 6-sulfate to C4S) were determined in the pulmonary melanoma tissues. This evidence concerns the gene CHST11 and melanoma.