ANPEP and Sepsis: APN levels showed a stronger association with 28-day survival than other factors, including the APACHE II score.12,26 Hillenbrand et al found significant changes in plasma adipokine levels in severe sepsis, with higher pro-inflammatory and lower anti-inflammatory factors.28 In our study, multivariate regression analysis indicated that 28-day mortality was significantly correlated with APN levels in patients <80 years of age.