ASXL1 and essential thrombocythemia: This contrasts with the single KO mice in which Asxl1 KO mice were largely normal with mild polycythemia vera–like or essential thrombocythemia–like hematopoietic phenotypes noted in some animals, whereas Ezh2 KO resulted in low penetrant MDS/MPN LPDs with extended disease latency (Figure 1D-H, supplemental Figure 1E-G; supplemental Table 2).