ASXL1 and essential thrombocythemia: Consistent with the respective disease phenotypes, Asxl1 KO diseased mice had elevated red blood cells, hemoglobin, and/or platelet levels in line with polycythemia vera–like or essential thrombocythemia–like phenotypes (Figure 1F; supplemental Figure 1E), whereas Asxl1/Ezh2 dKO showed left-shifted granulopoiesis with a significant increase in the percentage of myeloblasts and promyelocytes and a significant decrease of band cells (Figure 1G) with thrombocytosis (Figure 1F).