Mechanistically, PARPi sensitivity can be due to suppression of homologous recombination (HR) genes55,56 as we have previously reported for acute myeloid leukemia (AML) driven by repressive oncogenic transcription factors such as RUNX1/RUNX1T1 (AML1-ETO).40 This evidence concerns the gene RUNX1 and acute myeloid leukemia.