Although both CLL models shared several overlapping pathways (supplemental Figure 3D), DNA repair pathways were only found in Asxl1/Ezh2 dKO CLL (Figure 3H), which was further validated in GSEA analysis (Figure 3I), consistently suggesting excessive DNA damage being induced in Asxl1/Ezh2 dKO cells. The gene discussed is ASXL1; the disease is B-cell chronic lymphocytic leukemia.