Although no MDS/MPN-like disease phenotype was observed in mice that received secondary transplantation, aggressive CLL-like diseases developed with short latency in approximately half of the animals (6/13) transplanted with Asxl1−/−Ezh2−/− LPD cells but not Ezh2−/− LPD cells (Figure 2C). This evidence concerns the gene EZH2 and myeloproliferative neoplasm.