KMT2A and myelodysplastic syndrome: Strikingly, PARPi treatment very significantly suppressed the colony-formation ability in Asxl1−/−Ezh2−/−Runx1KD MDS cells and again had no notable impact on control MLL-fusion transformed cells (Figure 4E), suggesting a specific PARPi vulnerability was created and remained in Asxl1−/−Ezh2−/− cells despite the presence of additional genetic events.