The results showed that the AUC values of C5AR2, FCGR3A, and NFATC2 were 0.758, 0.611, and 0.609, respectively (Figure 6A-C), indicating that C5AR2 had good diagnostic accuracy, and FCGR3A and NFATC2 had sufficient diagnostic accuracy, and the three may be potential diagnostic markers of IDD. The gene discussed is FCGR3A; the disease is intervertebral disk degenerative disorder.