This present analysis possesses several strengths: (1) findings were robustly confirmed through TSA analysis, enhancing result reliability; (2) all incorporated studies adhered to the Hardy-Weinberg Equilibrium (HWE), contributing to the overall study reliability; (3) this systematic evaluation represents the inaugural analysis examining the relationship between CYP17A1 rs743572 and cancer risk; (4) FPRP analysis was applied to all significant observations. This evidence concerns the gene CYP17A1 and cancer.