A recent study from Nature [25] showed that the abnormal expression of the CHEK1 will promote the accelerated aging of women’s ovaries and previous studies have shown that the loss of ovarian health will promote women’s systemic aging, which will lead to increased risk of cardiovascular disease, bone disease and neurodegenerative diseases and eventually shorten women’s life expectancy [26]. This evidence concerns the gene CHEK1 and neurodegenerative disease.