Furthermore, markers indicative of cardiac hypertrophy, including the ratios of heart weight to body weight (HW/BW) and heart weight to tibia length (HW/TL), and the levels of serum atrial natriuretic peptide (ANP) and cardiac Myosin Heavy Chain (MyHC) and ANP proteins were markedly reduced in Ang II–induced YOD1−/− mice compared to those in WT mice (Fig. 1, M to O, and table S1). This evidence concerns the gene YOD1 and cardiac hypertrophy.