Excessive activation of the renin‐angiotensin‐aldosterone system (RAAS) plays a critical role in the progression of chronic kidney disease (CKD) (Brewster & Perazella, 2004; Saldanha da Silva et al., 2017) by triggering hemodynamic maladaptation and enhancing inflammation, fibrosis, and oxidative stress within the kidneys (Ba Aqeel et al., 2017; Brewster & Perazella, 2004; Cao et al., 2016; Chen et al., 2016; Chou et al., 2018; Saldanha da Silva et al., 2017). The gene discussed is REN; the disease is chronic kidney disease.