Relationship between OCT markers and five other neurodegenerative diseases were summarized in Table 3, The results show that changes in PRL and RPE may be specific to ALS: atrophy of the GCIPL, RNFL, macula, and optic disc may be more common in AD; a thicker GCIPL may be related to PD; a reduction in macular volume was observed in multiple system atrophy (MSA); atrophy of the PRL was noted in progressive supranuclear palsy (PSP). The gene discussed is PRL; the disease is amyotrophic lateral sclerosis.