After excluding individuals with a follow-up of less than 6 years, PRL (per SD increase HR [95% CI] = 0.82 [0.70, 0.97]; p = 0.018) and RPE (per SD increase HR [95% CI] = 1.19 [1.03, 1.37]; p = 0.015) remained significantly associated with ALS. This evidence concerns the gene PRL and amyotrophic lateral sclerosis.