In the multivariable Cox analysis, adjusted for age, sex, ethnicity, TDI, hypertension, diabetes, intraocular pressure, and spherical equivalent, the conclusions remain consistent: INL (per SD increase HR [95% CI] = 1.16 [1.04, 1.29]; p = 0.009), RPE (per SD increase HR [95% CI] = 1.20 [1.07, 1.34]; p = 0.002), and PRL (per SD increase HR [95% CI] = 0.81 [0.71, 0.93]; p = 0.002). The gene discussed is PRL; the disease is Hypertension.