Ultimately, we identified 16 intersection genes (ABCG4, CD24, DEFB103A, EPHB2, FABP5, HPSE, IFI16, KYNU, OAS3, OASL, PLA2G4D, PRSS27, SAMD9, SERPINB13, STAT1, TMPRSS11D) that have been designated as candidate hub genes that may be critical in the onset and progression of psoriasis (Fig 3C). This evidence concerns the gene HPSE and psoriasis.