In future studies, we will closely monitor relevant information from other databases and conduct in vitro research, with particular emphasis on the mechanisms underlying the role of the 5 characteristic genes (DEFB103A, OAS3, OASL, SAMD9, STAT1), 8 clinical outcome sensitive genes (DEFB103A, OASL, HERC6, ISG15, MKI67, MX1, MXD1, SCO2) and their associated pathways in psoriasis. Here, ISG15 is linked to psoriasis.