Moreover, the network diagram also reveals multiple core genes and transcripts directly related to cellular pathways associated with the onset and treatment of psoriasis, including IL-1B, IL-6, IL-17A, IL-18, CXCL8, INFG, STAT1, CD80, etc. These key nodes are highly correlated with the enriched pathway, suggesting that the biological mechanism of biomarkers such as interleukin and interferon may be one of the core mechanisms in the pathogenesis and treatment of psoriasis. Here, IL18 is linked to psoriasis.