CD8A and psoriasis: According to the GO analysis of BP shown in Fig 2E, a notable enrichment of BP terms associated with various psoriasis biological processes, including CD8 + alpha-beta T cell activation, interferon β production and T helper 17 type immune response, etc. The results were mainly enriched in 62 CC term sets, including specific granule lumen, vesicle lumen, condensed chromosome and centromeric region, etc. These results were similar to the GSEA results of the lesional and non-lesional cohort (Fig 2F).