Of these, COX17, ATP7A, MTF1, ULK2, PDK1, SOD1, MT1A, and MT2A were upregulated in AD groups, while FDX1, GLS, MAP2K1, SCO2, SCO1, PDHB, UBE2D4, PDHA1, UBE2D2, DLD, and DLAT were downregulated (Fig 2B). Here, ATP7A is linked to Alzheimer disease.