GLS and Alzheimer disease: Furthermore, we evaluated the expression levels of MAP2K1, FDX1, GLS, and PDK1 of these immunocyte types among AD samples and found that MAP2K1 and FDX1 were enriched in all cell populations; GLS was abundantly expressed in NK cells, B cells, and CD4+ T cells, whereas PDK1 was highly expressed among B cells, CD8+ T cells, and CD4+ T cells, which corresponded to the results of S2 Fig and Fig 11D (Fig 11E).