SCO2 and Alzheimer disease: Of these, COX17, ATP7A, MTF1, ULK2, PDK1, SOD1, MT1A, and MT2A were upregulated in AD groups, while FDX1, GLS, MAP2K1, SCO2, SCO1, PDHB, UBE2D4, PDHA1, UBE2D2, DLD, and DLAT were downregulated (Fig 2B).