Simulated molecular regulation networks and in vitro results support the notion that the KHDC4-TRAF2 axis contributes to tumor malignancy features in late-stage and lymph node metastasis tumor samples, consequently correlating with worse progression-free interval and disease-free interval prognosis values in TCGA-PRAD. This evidence concerns the gene TRAF2 and metastatic malignant neoplasm in the lymph nodes.