Adipose tissues also produce proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), whose levels are higher in MASH compared to hepatic steatosis, and interleukin-6 (IL-6), which promotes the development of HCC by inhibiting apoptosis and activating pro-oncogenic pathways [50]. This evidence concerns the gene IL6 and metabolic dysfunction-associated steatohepatitis.