Additionally, it was demonstrated that HYP inhibits ischemia/reperfusion-induced oxidative stress and cell apoptosis by controlling the OMA1-OPA1 signaling pathway in an experimental model for ischemic acute kidney injury using both in vitro HK-2 cell line systems and in vivo Male C57BL/6 mice (Wu et al. 2019). This evidence concerns the gene PHEX and acute kidney injury.