TP53 and endothelial dysfunction: Irisin attenuates type 1 diabetic cardiomyopathy by anti‐ferroptosis via SIRT1‐mediated deacetylation of p53,[39] it may also alleviate vascular calcification by inhibiting SMC osteoblastic transformation and mitochondria dysfunction.[40] Furthermore, irisin lowers blood pressure by improving endothelial dysfunction via AMPK‐Akt‐eNOS‐NO pathway in the spontaneously hypertensive rat[24] and protects macrophages from oxidized low‐density lipoprotein‐induced apoptosis by inhibiting the endoplasmic reticulum stress pathway.[41] In our study, we investigate the effect of irisin on metabolism.