ENO1 is upregulated in various tumors and plays a significant role in promoting tumor proliferation, resistance to apoptosis, migration and metastasis.[44, 45] Previous studies indicate that ENO1 regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK‐Akt pathway, which serves as a regulator of pathogenic metabolic reprogramming in hypoxia pulmonary hypertension.[46] However, the relationship between irisin and ENO1 regulation has rarely been investigated. The gene discussed is FNDC5; the disease is neoplasm.