CFL2 and neoplasm: Chen et al. performed the proteomic analysis of CNE2-RR cells secretome and reported CD166, cofilin 2 (CFL2), fibrillin 2 (FBN2), and sulfhydryl oxidase 1 (QSOX1) as potential markers involved in RT resistance due to their role in cell adhesion, migration, and invasion contributing to tumor cell plasticity, EMT, and metastasis [134].