The authors selected and validated checkpoint kinase 1 (CHK1), cyclin-dependent kinases 1 and 2 (CDK1 and CDK2), and TATA-box binding protein-associated factor 9 (TAF9) as proteins increased in RR cells, suggesting an important role of DNA repair, cell cycle, and transcription regulation in BC radioresistance. The gene discussed is CHEK1; the disease is breast cancer.