Low oxygen stabilizes the transcriptional hypoxia-inducible factors 1 alpha and 2 alpha (HIF-1α and HIF-2α), which enhance pathways essential for tumor growth and survival [54], such as angiogenesis, with the upregulation of vascular endothelial growth factor (VEGF) and metabolic shift toward glycolysis and lactate production (Warburg effect). The gene discussed is HIF1A; the disease is neoplasm.