Downregulation of Mdm2 levels affected the abundance of a number of proteins (Table S2), including Ras-related protein Rap-2c (RAP2C_HUMAN, upregulated, a GTP binding protein [60]), nucleus accumbens-associated protein 1 (NACC1_HUMAN, upregulated, a transcription repressor involved in tumor progression [61]), vigilin (VIGLN_HUMAN, downregulated, plays a role in sterol metabolism), and ADP-ribosylation factor GTPase-activating protein 3 (ARFG3_HUMAN, downregulated, a GTPase-activating protein [62]). The gene discussed is ARFGAP3; the disease is neoplasm.