This study also highlighted the significant roles of extracellular matrix proteins (PLOD2, OGN, and LUM) and membrane proteins (TYROBP, AOC3, SLC16A3, TCIRG1, and NCEH1) in RA pathogenesis, emphasizing their contributions to inflammation, tissue remodeling, and joint destruction. The gene discussed is SLC16A3; the disease is rheumatoid arthritis.