SOD1 and amyotrophic lateral sclerosis: Despite this, Fe-based therapeutics such as iron(III) meso-tetra(4-carboxyphenyl)porphyrin chloride (FeTCPP) have shown neuroprotective effects by scavenging reactive oxygen and nitrogen species and extending survival in SOD1 ALS models [73], suggesting that the impact of Fe depends on its biochemical form and compartmentalization.