These reported genes indicate that acute PM2.5 exposure induces mutation-specific transcriptional changes in NSCLC cells, with EGFR-mutant NCI-H1975 cells showing greater susceptibility due to oxidative stress, carcinogen activation, and immune suppression, underscoring the need for targeted interventions in high-pollution environments. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.