Park et al. reported that naringenin (200, 400, and 600 μM) downregulated peroxiredoxin-1 (PRDX1) and activated the apoptosis signal-regulation kinase 1 (ASK1) pathway through ROS production in SNU-213 pancreatic cancer cells [138]. The gene discussed is MAP3K5; the disease is familial pancreatic carcinoma.