Chang et al. reported that 5-acetyloxy-6,7,8,4′-tetramethoxyflavone (5-AcTMF), an acetylated tangeretin derivative (50 μM), inhibited glioblastoma multiforme cells and induced pro-apoptotic effects by suppressing the JAK2–STAT3–BCL-2/BCL-xL signaling axis (Table 2) [114]. The gene discussed is BCL2; the disease is glioblastoma.