The study revealed that seven licochalcone molecules, including glypallichalcone, echinatin, and 3,4,3′,4′-Tetrahydroxy-2-methoxychalcone, interfere with the cancer signaling pathway via the NF-κB signaling pathway, PDL1 expression, and the PD1 checkpoint pathway in cancer. The gene discussed is CD274; the disease is cancer.