This effect is due to the direct action of calcimimetics at the vascular level since, in preclinical studies, it has been shown that the expression of CaSR is altered in the context of arterial hypertension and calcimimetics could produce a dose-dependent vasodilatory effect, modulating vascular tone both in normal and pathological conditions (such as in hypertension) [43,44,45,46]. The gene discussed is CASR; the disease is Hypertension.