Moreover, the recent development of an E. coli O157/O145 LFIA (lateral flow immunoassay) has allowed the detection of specific IgM antibodies very early in the course of the infection, making it an ideal diagnostic tool to be implemented in pediatric emergencies and, thus, avoid delays in the application of the correct supportive or specific treatment and prevent complications associated with HUS [122]. This evidence concerns the gene CD40LG and infection.