A decade ago, Kv1.2 emerged as a key factor in neurologic excitability disorders when Syrbe et al. identified gain-of-function mutations R297Q and L298F in the KCNA2 gene of patients exhibiting early-onset epileptic encephalopathy (EE), intellectual impairment, motor delay, and ataxia [15]. This evidence concerns the gene KCNA2 and Cognitive impairment.