It has been demonstrated that, in an LPS-induced endometritis model of cows, the activation of Nrf2 by the flavonoid fisetin promotes the expression of antioxidant enzymes such as HO-1 and inhibits the accumulation of ROS, thereby blocking the activation of NF-κB and indirectly suppressing COX-2 expression. The gene discussed is NFE2L2; the disease is endometritis.