By focusing on the survival analysis of the nodal large-cell lymphomas, animals with CL classified as highly proliferative in CBs (Ki67 > 12.2%) and treated with chemotherapy survived on average 124 days (median 57 days), while animals not treated with chemotherapy had 67 and 40 days of mean and median survival times, respectively. The gene discussed is MKI67; the disease is anaplastic large cell lymphoma.