In line with this, a model of brain metastasis from breast cancer showed that neuroprotectin D1, a DHA derivative, can accelerate lipid droplets’ breakdown and release ω-6 PUFA by activating adipose triglyceride lipase (ATGL), leading to an imbalance of the ω-6/ω-3 ratio in the lipid composition of metastatic cell membrane. This evidence concerns the gene PNPLA2 and breast cancer.