For example, bromophenols isolated such as rosmarinic acid(12) (see Figure 1L for chemical structure) and its liposomes from red algae can significantly enhance the demethylation effect of histone deacetylase (HDAC) inhibitors on the promoter region of TfR1, and this epigenetic remodeling makes tumor cells 3.2-fold more sensitive to ferroptosis [81]. The gene discussed is TFRC; the disease is neoplasm.