ACSL4(1)-driven lipid peroxidation ACSL4(1) (long-chain acyl-coa synthetase 4), as the core regulator of ferroptosis, plays a key role in tumor ferroptosis by catalyzing the binding of PUFAs to coenzyme A and driving the lipid peroxidation process of cell membrane phospholipids [72,73]. This evidence concerns the gene ACSL4 and neoplasm.