For example, didemnin B derived from sea squirt can achieve a synergistic effect of ferroptosis induction and immune microenvironment remodeling in a pancreatic cancer model by blocking eukaryotic translation initiation factor (eIF) activity and inhibiting GPX4 protein synthesis and lipid uptake-related genes’ (such as FABP4) expression of TAMs [114]. This evidence concerns the gene GPX4 and familial pancreatic carcinoma.