Recently, it has been reported that hyperglycemia-induced inflammation in the hippocampus depends on the direct binding of RAGE expressed in microglia to serine/threonine protein kinase 1, and this mechanism is important in enhancing neuroinflammation in a hyperglycemic environment and is a key node in the development of cognitive impairment in diabetes [33]. The gene discussed is CDK7; the disease is Cognitive impairment.