Melanoma, known for its aggressive metastatic behavior, is significantly influenced by EMT; this process is characterized by the transition from E-cadherin to N-cadherin, along with the upregulation of genes like vimentin, slug, and snail, which enables melanoma cells to form N-cadherin-mediated adhesion with stromal fibroblasts [10]. The gene discussed is CDH2; the disease is melanoma.