Exosomal proteomes have identified several exosomal proteins, including CD317, EGFR, leucine-rich a2-glycoprotein (LRG1), alpha-2-HS-glycoprotein (AHSG), and extracellular matrix protein 1 (ECM1), that hold the potential to serve as indicators for lung cancer early detection [47]. Here, ECM1 is linked to lung cancer.