For example, Antisense Noncoding RNA in the INK4 Locus (ANRIL), which resides in the cardiovascular disease susceptibility locus 9p21, encodes a lncRNA that regulates Cyclin-Dependent Kinase Inhibitor (CDKN)2A and B expression or circularizes to mediate atherogenic functions [13,14,15]. This evidence concerns the gene CDKN2A and cardiovascular disorder.