Individual roles of IRF2BP2, as well as its interaction with IRF2 in the IRF2/IRF2BP2 repression complex, have been described in autoimmune diseases [71,72,73], including asthma [74], multiple sclerosis [75], atopic dermatitis [76], and psoriasis [77], where CHROMR has been implicated [23,24,26]. Here, IRF2 is linked to multiple sclerosis.