PRKRA and asthma: Using a first-stage analysis of 49,953 individuals (7098 patients with asthma and 36,578 controls), followed by a second-stage analysis of an additional 17,280 asthma cases and 115,562 controls, the research identified an asthma-associated CNV on chromosome 2 leading to the duplication of exons 4–8 of PRKRA and the 3′ end of CHROMR [24].