IL10 and Q fever: On the other hand, several mouse models have elucidated important aspects of the pathogenesis of Q fever, such as mice with SCID (severe combined immunodeficiency) strains that developed endocarditis with focal calcifications very similar to those seen in humans, mice overexpressing IL-10 with reduced granuloma formation and accumulation of Coxiella burnetii in tissues, and knockout mice lacking TLR-2 or IFN-γ that exhibited a febrile response to Coxiella burnetii phase II.