IL6 and COVID-19: The effectiveness of the downstream blockade at the BKB2R level (i.e., close to the final effector steps of vasodilation and oedema production) speaks of a funnel effect for which more upstream interventions would be comparatively less efficacious and sheds light on the paradox that general anti-inflammatory therapies (i.e., corticosteroids) have proved more beneficial than selective kinase inhibitors and IL-6 inhibitors against COVID-19 [35].