IGHE and atopic asthma: Subsequently, a metabolomic analysis of the serum and a 16S rRNA sequencing of the intestinal microbiota were conducted on 3 different cohorts of children, including 15 children with poorly sensitized non-atopic asthma, 13 with highly sensitized atopic asthma and 25 healthy controls [21] together with an integrative analysis to assess the presence of associations between the two asthmatic endotypes and allergen-specific IgE levels.