This latter profile, characterized by a low-grade systemic inflammatory state typical of obesity, is supported by the activation of M1 macrophages, responsible for the production of IL-6, TNF-α and IL-1β and the triggering of Th1 and Th17 cells, as the basis of neutrophilic inflammation. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.