Current cross-sectional study using UPLC-MS/MS to quantify 28 plasma and fecal bile acids in 200 paired individuals (100 treatment-naive T2DM patients and 100 BMI-matched NGR controls) found that plasma levels of DCA, iso-DCA, and 12epi-DCA were significantly elevated in T2DM and that both plasma and fecal DCA were associated with HOMA-IR, fasting blood glucose (FBG), glycated hemoglobin (HbA1c), and insulin, highlighting a strong link between DCA and impaired glucose metabolism [102]. The gene discussed is INS; the disease is type 2 diabetes mellitus.