Even though the majority of LPCs are formed from oxidized phospholipids (PPLs), plasma LPC(20:4) and LPC(22:6) come from the action of human lecithin cholesterol acyltransferase (LCAT) [43]; however, low LCAT activity in diabetic patients, particularly in women, was reported [44], which is contradictory to the apparently higher levels of LPC(20:4) in the T2DM group found in this study. This evidence concerns the gene LCAT and type 2 diabetes mellitus.