For example, decreased HDL cholesterol levels have been linked to the presence of an SNP in the ATP Binding Cassette Subfamily G Member 1 (ABCA1) gene in patients with cardiovascular conditions [21], whereas Carnitine O-Octanoyltransferase (CROT) gene, which is involved in mediating the transfer of fatty acids to mitochondria for β-oxidation, has been proposed as a contributor to MASLD progression, possibly through increased de novo hepatic fat synthesis, inflammation and fibrosis [22]. This evidence concerns the gene CROT and metabolic dysfunction-associated steatotic liver disease.