TRIB3 and cancer: Tribbles-related protein 3 (TRIB3) has a role in the antitumoral activity of capsaicin in humans and its function as apoptosis regulation [123]; during this study, they tested a set of different cancer cell lines and achieved to identify that capsaicin enhances TRIB3 gene expression, which allowed an increase in the antiproliferative and proapoptotic effects of TRIB3 in cancer cells and contributed to the understanding of TRIB3’s role in cancer cell death as shown in Figure 7.