TXNIP and gestational diabetes: In placental tissues from obese and non-obese pregnant women, including a subgroup of 10 obese women with GDM, TXNIP expression levels have been found to be positively correlated with placental thickness and negatively correlated with placental surface area, both critical morphological factors related to the placenta’s efficiency to transfer oxygen and nutrients to the fetus [106], suggesting a relationship between placental oxidative status and placental alterations.