This study evaluates the inhibitory potential of two triphenyltin(IV) derivatives—(3-propan-1-ol)triphenyltin(IV) (Ph3SnL1) and (4-butan-1-ol)triphenyltin(IV) (Ph3SnL2)—in both free form and immobilized into mesoporous silica SBA-15~Cl, targeting acetylcholinesterase (AChE), a key enzyme involved in AD pathophysiology. The gene discussed is ACHE; the disease is Alzheimer disease.