The mechanisms are different for different representatives of the group, but one of the most common is the inhibition of microtubule polymerization and mitotic arrest, activation of caspase-dependent apoptosis via the mitochondrial pathway, inhibition of angiogenesis through reductions in vascular endothelial growth factor (VEGF) signaling, DNA topoisomerase inhibition, induction of oxidative stress-mediated apoptosis, and other interferences crucial for cancer cell signaling pathways [116,117]. Here, VEGFA is linked to cancer.