Interestingly, previous literature pointed out that SH-SY5Y human neuroblastoma cells, when differentiated by combined treatment with brain-derived neurotrophic factor (BDNF) and retinoic acid, clearly express mRNA for NR1, NR2C, and NR2D, with very weak expression of NR2A mRNA. This evidence concerns the gene GRIN2D and neuroblastoma.