YTHDC1 and precursor B-cell acute lymphoblastic leukemia: A small-molecule inhibitor of histone H3K79 methyltransferase, EPZ-5676, has been reported to inhibit YTHDC1 and impair DNA repair in B-cell lymphoblastic leukemia (B-ALL), resulting in reduced cell proliferation and enhanced cytotoxicity to chemotherapeutics in B-ALL mouse models [78].