Neurofibromatosis type 1 (NF1) and Neurofibromatosis type 2 (NF2), tuberous sclerosis complex (TSC), von Hippel–Lindau disease (VHL), Sturge–Weber syndrome (SWS), and ataxia–telangiectasia (A-T) exemplify this group. This evidence concerns the gene NF1 and tuberous sclerosis.