For instance, in a molecular analysis, methylation-specific PCR of the genes FLIP, TSP1, DcR1, DcR2, DR4, DR5, CASP8 and HIC1 was implemented on 20 neuroblastomas, 23 VHL-associated pheochromocytomas and 16 sporadic pheochromocytomas [65]. This evidence concerns the gene CASP8 and hereditary pheochromocytoma-paraganglioma.