There were also differences between VHL disease-related cRCCs and sporadic RCCs since 11 genes (RASSF1, TWIST1 PITX2, CDH13, HS3ST2, TAL1, WT1, MMP2, DCC, ICA1 and TUSC3) were more frequently methylated in sporadic tumors and 1 (GABRB3) was more frequently methylated in VHL tumors. This evidence concerns the gene VHL and von Hippel-Lindau disease.