Susceptibility to OM has been found to be associated with polymorphisms in genes involved in the folic acid metabolic pathway (MTHFR gene), transport proteins (SLCO1B1, ABCB1, ABCC2, and ABCG2 genes), epigenetic machinery (miR-1206 and miR-3683 genes), oxidative stress (CAT gene) and vitamin D metabolism (VDR gene) [17,19,20,22,25,27,29,31,32,34,35,36,37]. This evidence concerns the gene CAT and ocular melanoma.